OBG AND GYNAE

Progesteron is a hormone secreted by the female reproductive system that functions mainly to regulate the condition of the inner lining (endometrium) of the uterus. Progesterone is produced by the ovaries, placenta and adrenal glands. In the  ovaries the site of progesterone production is the corpus luteum. Progesterone prepares the wall of the uterus so that the lining is able to accept a fertilize egg and so that the egg can be implanted and develop. It also inhibit muscular contractions of the uterus that would probably cause the wall to reject the adhering egg. A fertilized egg that becomes implanted in the uterus will form a placenta The placenta then produces progesterone during the period of pregnancy If the egg is not fertilized, progesterone is secreted by the ovaries until a few days before menstruation, at which time the level of progesterone drops sufficiently to stop the growth of the uterine wall and to cause it to start to break down, and menstruation ensues.

Progesterone is known to have effects on other female organs. In the overies progesterone and estrogens are thought responsible for the release of an egg during ovulation. It is believed that if the egg is fertilized, these hormones are influential in the prevention of further egg release until the pregnancy has terminated. This dual action ordinarily prevents the release and of more than one egg at one time, although two or more eggs are occasionally released. In the fallopian tubes progesterone is thought to stop the muscular contractions in the tube once the egg has been transported. During Pregnancy progesterone also stimulates development of the glands in the breasts that are responsible for milk production.

Folate /vitamin B9 is an essential nutrient that is required for DNA replication and as a substrate for a range of enzymatic reactions involved in amino acid synthesis and vitamin metabolism. Demands for folate increase during pregnancy because it is also required for growth and development of the fetus. Folate deficiency has been associated with abnormalities in both mothers (anemia, peripheral neuropathy) and fetuses (congenital abnormalities).
The term ‘Folate’ is typically used as a generic name for the group of chemically related compounds based on the folic acid structure. Folate, or vitamin B9 is thought of as one of the 13 essential vitamins. It cannot be synthesized by the body, and must be obtained either from diet or supplementation. Dietary folate is a naturally occurring nutrient found in foods such as leafy green vegetables, legumes, egg yolk, liver, and citrus fruit. Folic acid is a synthetic dietary supplement that is present in artificially enriched foods and pharmaceutical vitamins. Neither folate nor folic acid is metabolically active. Both must be reduced to participate in cellular metabolism. L-5 Methyltetrahydrofolate (L-methylfolate) is the predominant micronutrient form of folate that circulates in plasma and that is involved in biologic processes.

vitamin B12/methylcobalamin deficiency has been associated with increased risk of common pregnancy complications, including spontaneous abortion, low birth weight, intrauterine growth restriction and neural tube defects.Children born to vitamin B12-deficient women are at increased risk for adverse health outcomes, including developmental abnormalities and anaemia.

The beneficial effects of pyridoxine/B6 supplementation for pregnant and breast-feeding women have been widely demonstrated. Considering that pyridoxine plays a crucial role in the development and functioning of the neonatal brain, providing pyridoxine supplementation directly to neonates could have a favorable effect on their neurological development. it is often recommended for use in pregnancy to reduce morning sickness, and has been used in antiemetic drugs.

Norethisterone is a synthetic form of progestin and has a similar action to the female hormone, progesterone. It is used to treat menstrual disorders and abnormal vaginal bleeding in women caused due to hormonal imbalances. It is also used for birth control to prevent unwanted pregnancies.

Therapeutic indications:

Dysfuntional Uterine Bleeding:
-Polymenorrhoea
-Dysmenorrhoea
-Menorrhagia
-Metropathia
-Haemorrhagia
Pre-menstrual syndrome
Postponement of menstruation

A controlled-release drug or preparation is released into the body in specified amounts over a specified period of time. The controlled-release system is designed to release the drug’s active ingredient gradually over the day.

The Controlled released technology  used in Evanort CR offers once a day dosing, Steady state serum concentration for desired result and thus reduces frequency of conventional dosing of  Norethisterone and reduces blood loss by 80%, This will help in HB rise.and improves Quality of life….

There are two types of dietary iron, haem, found in meat products, and non-haem, mainly present in plant foods; the bioavailability (the amount able to be absorbed and used) of iron from these forms is quite different. While the absorption of haem iron is generally very good, less iron is absorbed from non-haem sources due to the influence of other common dietary substances which inhibit iron absorption (e.g. phytates, polyphenols and tannins) and because of its non-dissolvable structure.

ferrous bisglycinate is a  chelated form of non-haem iron that passes through the stomach and small intestine without breaking apart. It has been shown to be more effectively absorbed than other types of iron chelate in healthy people with different iron levels.

This combination medication is used to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. It may be used to treat conditions caused by low calcium levels such as bone loss), weak bones, decreased activity of the parathyroid gland, and a certain muscle disease (latent tetany). It may also be used in certain patients to make sure they are getting enough calcium (e.g., women who are pregnant, nursing, or postmenopausal, people taking certain medications such as phenytoin, phenobarbital, or prednisone).

Calcium plays a very important role in the body. It is necessary for normal functioning of nerves, cells, muscle, and bone. If there is not enough calcium in the blood, then the body will take calcium from bones, thereby weakening bones. Vitamin D helps your body absorb calcium and phosphorus. Having the right amounts of vitamin D, calcium, and phosphorus is important for building and keeping strong bones.